Benefits and Hazards of High Oxygen Partial Pressure

Oxygen is necessary to sustain life, but it plays a more complex role in diving safety. Increased fractions can improve decompression efficiency by reducing the inert gas fraction of inspired gas, and a high partial pressure of oxygen (PO2) is a staple in the treatment of decompression sickness. Problematically, however, too much oxygen can also create health and life-threatening toxicity. This article is drawn from a longer review of the topic (Pollock 2019).

The Oxygen Continuum

PO2 represents the product of the fraction of oxygen (FO2) multiplied by the ambient pressure (PO2 = FO2 * ambient pressure). PO2 is normally reported in atmospheres (atm). The PO2 of air at sea level pressure is 0.21 atm (0.21 * 1 atm). The PO2 delivered by open-circuit systems increases and decreases as a function of ambient pressure. For example, the PO2 of open-circuit air breathed at 1 msw (3 fsw) is already 0.23 atm (0.21 * 1.1 atm). The PO2 of open-circuit air breathed at 20 msw (66 fsw) is 0.63 atm (0.21 * 3.0 atm).

Oxygen Toxicity

Pulmonary oxygen toxicity involves irritation of lung tissue caused by prolonged breathing, often for many hours, of substantially elevated oxygen concentrations. This can develop with a PO2 as low as 0.5 atm given sufficient exposure time. Signs and symptoms include persistent unproductive cough, a sense of tightness in the chest or discomfort during inspiration, and pain behind the sternum. Mild symptoms typically resolve without consequence in the hours following a return to air breathing. One of the reasons that immersion pulmonary edema (IPE) may be missed is that mild symptoms can be attributed to pulmonary oxygen toxicity.

Central nervous system (CNS) oxygen toxicity involves an insult to the brain caused by exposure to higher PO2. This can develop after relatively short periods given high enough values. Signs and symptoms include twitching of facial muscles, tunnel vision, nausea, paresthesia, unconsciousness, and convulsions. Subtle manifestations may appear first, but cases can evolve rapidly or immediately present with fully incapacitating effects. The risk for CNS toxicity increases beyond a PO2 of 1.3 atm (Arielli et al. 2006). CNS toxicity represents a substantial threat since a loss of consciousness underwater is accompanied by a high risk of drowning.

 

Ocular oxygen toxicity is another possibility. Hyperbaric myopia (nearsightedness) can develop in both patients receiving hyperbaric oxygen (HBO) therapy and divers exposed to high PO2. This condition requires repetitive exposure over a fairly short period. It is increasingly likely after 15 or more HBO sessions and can develop at a variable rate with divers breathing high PO2. The visual changes typically resolve fully within the weeks following the end of exposure.

 

A more worrisome form of ocular oxygen toxicity involves the promotion of cataracts. Cataracts usually develop as a progressive cloudiness forming in the lens of the eye, producing blurry and impaired low light vision. Cataract formation is generally not reversible, ultimately requiring surgical replacement of lenses. The appearance or acceleration of cataracts has been reported in HBO patients. There is little firm evidence to date, but there are legitimate concerns that frequent and long duration dives at high PO2 could create a cataractogenic risk for divers. This is a good reason for additional mindfulness regarding oxygen exposure.

 

High Oxygen Utility and Concerns

 

Oxygen toxicity is less of a concern with open-circuit diving since peak PO2s are generally breathed for relatively short periods. It is a critical consideration in closed-circuit rebreather diving as high PO2 is maintained at a "setpoint" throughout most of dives.

 

A high PO2 setpoint is desirable to reduce decompression stress on divers. The higher the setpoint, the less inert gas will be taken up during the descent and bottom phase, and the more that will be eliminated as the diver ascends, particularly in the latter part of the ascent. The PO2 of air breathed on open-circuit is 1.3 atm at roughly 52 msw (171 fsw). A closed-circuit rebreather operating on a fixed 1.3 atm PO2 setpoint would deliver a progressively lower inert gas partial pressure from this point through the ascent. With a PO2 setpoint of 1.6 atm, a rebreather diver would inspire virtually no inert gas at a depth of 6 msw (20 fsw), producing a steep gradient for inert gas elimination.

 

Minimizing decompression stress is important, but oxygen toxicity is also a critical consideration of high PO2. It is tempting to downplay concerns of acute high PO2 when HBO therapy used to treat decompression sickness can expose patients to a PO2 of 2.8 atm, but there are critical differences that reduce the CNS toxicity risk in a dry chamber. HBO treatment includes scheduled air breaks to reduce the likelihood of adverse reaction; patients remain at rest; and, most importantly, a patient convulsing in a chamber can be simply managed by removing the oxygen mask or hood and clearing the airway as required.

 

Divers in the water face much greater hazard with any impairment of consciousness. Self-rescue capability is lost and rescue by others is far from assured. Full-face masks or mouthpiece retaining straps reduce the likelihood of losing the mouthpiece, but they do not address the airway compromise associated with vomiting into a mouthpiece or the loss of buoyancy control. The threshold for seizures may also be lower in the water, driven by exercise, rising arterial CO2 (associated with exercise or inadequate CO2 removal), increased work of breathing, general stress, cold (or cool) stress, and a wide range of medications or drugs that divers might use without being aware of potential interactions.

 

High Oxygen Limits

 

The PO2 limit of 1.6 atm has a long history in scientific, occupational, and technical diving. There is, however, a broad shift in practice towards more conservative bounds. The default high setpoint on many modern rebreathers is 1.3 atm. It is not uncommon for lower PO2 setpoints to be used for part or all of long exposures. Both the US National Oceanic and Atmospheric Administration (NOAA) and the Canadian Standards Association Z275.2 committee reduced the maximum PO2 during the working phase of dives from 1.6 to 1.4 atm in 2015, coming closer in line with the standard 1.4 atm PO2 recreational limit.

 

PO2 limits should reflect a compromise between the benefit of reducing decompression stress and the hazards of oxygen toxicity. A reasonable risk-benefit balance can be achieved by moderating PO2 during the deep phase of a dive where the absolute reduction in inert gas uptake is modest and the life threat from compromised consciousness is extremely high. A lower setpoint at depth would allow more flexibility to increase the PO2 during the shallower portion of the ascent where the decompression benefit of high PO2 is great and the life threat of compromised consciousness is somewhat reduced. Moderating the total oxygen dose (a function of concentration and duration) may offer some protection for all forms of toxicity, including potentially serious ocular effects.

The argument that the 1.6 atm PO2 limit has been well-tested through time is not fully valid. The existence of a limit is immaterial unless a large number of exposures are made to the limit. Exposures conducted partially or wholly at lower PO2 will not provide insight into the safety of higher PO2. There is a sufficient combination of documented evidence and theoretical concerns to encourage the use of modest PO2 limits to ensure safe exposures and to potential avoid long term risks.

 

Addressing Knowledge Gaps

 

More research is needed to better understand both the hazards and benefits of high PO2, and the wide variability of risk between individuals and between exposures. It is difficult to conduct research on potentially high consequence events, but the diving community can help by reporting details for all cases of oxygen toxicity, regardless of the severity or of the outcome. Extensive data are required to refine the guidance and to develop the capabilities of monitoring systems.

 

Conclusions

 

High PO2 offers both benefit and risk to divers. A reduction in decompression stress must be balanced against an increased risk of oxygen toxicity. Change in practice has led to some decrease in PO2 norms, but further research is needed to better understand variables that affect susceptibility to oxygen toxicity and the severity of outcomes. Additional information will almost certainly prompt further refinement of guidelines and practice.

 

 

Reference

 

Arieli R, Shochat T, Adir Y. CNS toxicity in closed-circuit oxygen diving: symptoms reported from 2527 dives. Aviation, Space, and Environmental Medicine. 2006; 77(5): 526–532.

 

Pollock NW. Oxygen partial pressure - hazards and safety. In: Cote IM, Verde EA, eds. Diving for Science 2019: Proceedings of the AAUS 38th Scientific Symposium. American Academy of Underwater Sciences: Mobile, AL; 2019: 33–38.

 

6 Responses

  1. Avatar Adrián González

    It´s very interesting. Iwas surprised to read the relationship with cataracts.
    Thanks

    Reply
  2. Avatar Suzanne Roat

    Neal,

    Thank you for an insightful article on the subject of high pPO2. I experienced hyperbaric myopia last summer after 10 days of rebreather diving in a 2 week period. My vision was so bad initially that I refrained from driving for 2 weeks after returning home. Very disconcerting!!

    I was already in a protocol of eye checks for posterior vitreous detachment — a case of “non-floating floaters”. I had a retinologist exam several days after returning home. Even with my 20/40 corrective lenses, the ‘A’ at the top of the eye chart was blurry. A visit to my regular eye doctor revealed my vision was worse than 20/70. A subsequent check 2 months later indicated my vision had reverted to state previous to extended dive holiday, no change in correction required.

    During the 10 days of diving in a 2 week period, my dive buddy experienced no such changes to vision. My buddy had cataract surgery with lens replacement several years prior.

    In future, I plan to be more conservative with my dive trip planning as well as pPO2 during dives. Your suggestion of opting for a lower pPO2 during deeper, early portion of dives makes sense to me.

    I share this in hopes others who may have experienced similar also share. I am curious to know.

    Again, thanks for the article.

    Regards, Suzanne

    Reply
  3. Avatar Nick Butcher

    Interesting comments on the effects of hyperbaric O2 on the eyes. I first encountered this on a dive trip to Bikini in 2012 and, although the doctor on the boat knew about this (and had experienced it somewhat himself), I found it very difficult to find out more once I returned home.

    My eyesight never fully recovered and was made a lot worse on a return trip in 2014. I was shortly afterwards diagnosed with cataracts which developed very quickly. I had cataract treatment in 2016 and now have trifocal intraocular lenses which are great (and seemingly unaffected by diving).

    I’m lead to believe this affects older people (I was 54 the first time I experienced this, as was the dive doctor on the boat. I’ve never met any younger divers who’ve suffered it.

    Reply
  4. I almost exclusively dive Nitrox on all dives for various reasons and rarely dive air unless doing very shallow dives that don’t warrant Nitrox, e.g. depths no deeper than 15/16m.

    That said my OTUs are never high after two dives, even after using EAN50 for deco. My general local dives are 27-30m for 30-40 mins using EAN34 then switching to EAN50 at 21m to surface.

    My second dive is generally on EAN40 for 18-24m dives depending on the site.

    During the past two years I have not required the use of spectacles to read text in books or the internet, I’m currently 66 yrs old and started wearing reading glasses from about the age of 45, which I no longer need.

    I am concerned about the risk of cataracts though, this is something I was unaware of. I have been diving for over 30 years.

    Reply
  5. Avatar Nico Verhoek

    Interesting article.
    Lately there was a Dutch marine diver doctor who obtained his PhD on Tuesday 10 March at the University of Amsterdam on the subject of pulmonary oxygen toxicity. You can find his dissertation on this site: https://dare.uva.nl/search?identifier=5a2bc958-2815-4b60-8f10-f8ea0a81f2ca

    Reply
  6. Avatar Neal Pollock

    I appreciate everyone sharing their experience. This can help readers appreciate both subtleties and idiosyncracies. Awareness is key to thoughtful planning.

    Reply