Immersion Pulmonary Edema

“I can’t breathe!”. Bill was a middle-aged man with a history of high blood pressure who was enjoying a wreck dive off the Northeast United States. He was diving a 14/7 mm farmer john wetsuit for the 51 degree water and diving EAN 29. Suddenly, he felt the urge to cough and a few seconds later he was panting and unable catch his breath. He frantically signalled to his buddy and bolted for the surface.

The crew of the dive charter got him back onboard and on oxygen. The Coast Guard was called and took him to a local hospital where he was completely asymptomatic upon arrival. He was monitored overnight and discharged home the following morning with a recommendation to follow up with a physician knowledgeable in diving medicine.

 

What happened?

Immersion pulmonary edema (IPE) is a very uncommon condition first reported in 1989. First described in diving in cold water, it was originally coined “cold-induced pulmonary edema”. However, it has now been reported in warm water diving as well. The condition presents as a combination of shortness of breath, cough, and frothy sputum. The absence of chest pain helps differentiate it from pulmonary decompression sickness (“chokes”) or a heart attack. Chest pain is only present in about 8% of cases.

It is not depth related and can occur at any point during a scuba dive. It frequently occurs in otherwise normal individuals and can even occur while swimming at the surface with an incidence of 1.3% in combat swimmers and in 1.4% of triathletes.

The exact mechanism is unknown, but it is felt likely to be due to a combination of the effects of increased pressure in the capillaries (small blood vessels) in the lungs that occurs with immersion in water coupled with a pressure gradient between mouth pressure and hydrostatic pressure at the chest in the upright position. Diving causes more negative pressure in the lungs during breathing due to the increased density of gas under pressure and can be worsened further by a poorly tuned regulator.

It is known that the physiologic effects of scuba diving include the immersion effects of a rapid distribution of blood from the extremities to the chest increasing the blood volume in the chest by up to 700 cc. This causes an increase in right atrial pressure by 16-18 mm Hg, an increase in cardiac output by 30%, and a slight increase in blood pressure.

Divers with conditions such as hypertension or underlying cardiovascular disease, especially if they have weakened heart muscle function, are less able to tolerate these physiologic changes and are more prone to develop pulmonary edema (fluid in the lungs). No large studies have been performed, but review of the medical literature shows several small series of patients with IPE with most reporting a higher proportion of women, and a high percentage of subjects with hypertension or cardiovascular disease. Approximately 50% of IPE patients will be found to have underlying cardiovascular disease.

Over-hydration has been implicated in a number of cases. So, while divers often worry about their risk of dehydration-associated decompression illness and drink lots of fluids to avoid this, drinking too much fluid can predispose a diver to IPE. When it comes to fluid intake, the medical recommendation is “thoughtful hydration”. Don’t overdo it.

Other possible precipitating causes include a tight fitting wetsuit where compression of the chest makes the work of breathing more difficult and the compression of the extremities can result in a greater amount of blood being shunted from the peripheral to the central circulation.

Several publications have suggested that hyperoxia may predispose a diver to IPE which is concerning for rebreather divers.  Repetitive deep dives have also been reported to result in an increased risk of IPE, presumably due to the increased bubble load resulting in injury to the blood vessel walls in the lungs and a resultant leakage of fluid into the lungs.

IPE can be difficult to diagnose and is likely underreported as it can be confused with other conditions such as salt water aspiration, pulmonary barotrauma, pulmonary decompression sickness (chokes), respiratory infection, or a heart attack.

How is IPE treated?

First and foremost, the treatment is to get the victim out of the water. Symptoms will continue to worsen in the water, even on the surface. Once out of the water, the victim should be given supplemental oxygen. Bronchodilators or diuretics (“water pills”) can be used but are often not required as the majority of patients will resolve their symptoms within hours after the event. Continuous positive airway pressure therapy (CPAP) and Bilevel Positive Airway Pressure therapy (BiPAP) are more effective than diuretics if symptoms persist.

Under what circumstances can someone who experienced IPE return to diving?

Unfortunately, very little is known about the likelihood of recurrent IPE once a diver has had an episode. After an episode of IPE, there is often spontaneous recovery once the diver leaves the water. If not, it tends to respond to standard therapy for pulmonary edema, such as diuretics. Whether or not a diver should return to diving after an episode of IPE should be determined on a case by case basis. The decision should be based on the physical condition of the diver, a history of hypertension or cardiovascular disease, and the type of diving being considered. Obviously, shallow warm water diving in a young healthy diver who suffered a mild case of IPE is less concerning than a middle-aged diver with multiple medical problems who wants to return to cold water diving after a severe episode of IPE that required hospitalization. Recurrence rates of 16-17% have been reported in the medical literature.

Case Follow up

Bill’s symptoms improved immediately upon getting out of the water and, on oxygen, had completely resolved by the time he arrived at the hospital. His admission chest x-ray was normal. He was monitored overnight and discharged home the following morning. As an outpatient he had an exercise stress test and an echocardiogram (ultrasound of the heart) which were both normal. Bill has returned to diving, but only in the warm waters of the Caribbean.

In retrospect, Bill had been off his diuretics for two days prior to the event and remembered having similar, but less severe, episodes in the past. He had gained some weight causing his wetsuit to be quite tight and he was diving in cold water. He developed classic symptoms of shortness of breath without chest pain and all symptoms resolved within about 90 minutes of getting out of the water.  This was a classic case of IPE.

What about IPE do we not understand?

Despite the best efforts of many investigators, the medical community does not know much about IPE.  Until we better understand the mechanism of the disorder and who is predisposed to it, it is difficult to make recommendations to divers as to how to avoid it or when to return to diving after an episode.

Current recommendations would be:

  1. Use appropriate thermal protection, emphasizing functionality and fit
  2. Thoughtful hydration
  3. Good physical fitness and health
  4. Realize that recurrences are common and plan accordingly

 

If you or anyone you know has suffered from pulmonary edema, please contact Dr. Richard Moon, a world expert on Immersion Pulmonary Edema, and consider enrolling in one of his research trials for immersion pulmonary edema patients. He can be contacted at:

Richard Moon, MD

Profession of Anesthesiology and Medicine

Duke University Medical Center

Durham, North Carolina

Telephone 919-684-8762

4 Responses

  1. Stuart Serediuk

    As a diver in this demographic, I found this article very interesting. Keep them coming please.

    Reply
  2. Guys …. its called reverse pulmonary oedema and its not nice !

    Reply
  3. Bob Sweeney

    I have found that I am susceptible to this condition. I primarily dive cold, Great Lakes water using a rebreather. I have only experienced it once in warm waters (Maui) and maybe 5-6 times in cold water. I have never had a severe reaction but have learned the initial symptoms so I call the dive quickly when I start to notice a ‘tickle’ in my air passageway. It seems to happen to me when I have a lot of fluid intake the day before so I monitor that prior to diving as much as possible. I added heated garments to my dry suit and a manual diluent valve to reduce some of the known factors that bring it on. I have greatly reduced my decompression diving due to this potential, luckily it hasn’t been a problem during a deco dive.

    Reply
  4. Mark Strong

    Having obtained NAUI cert in mid 70’s and experiencing ‘a lot’ of great (and not so great) dives, would present a very simplistic view of the activity many may take exception with. Oh well… here it goes.

    Using ‘regular air’ with a typical 70 cft @ 3000 psi (hopefully) tank, unless one is in the navy or a ‘working’ diver, following ‘basic’ practices will never require a sport diver to need anything other than a depth and tank pressure gauge.

    Assuming you do not wander deeper than ~ 120′ (forget everything else – it is all about how fast you can surface if your air becomes unavailable – suddenly – and not relying on a backup or partner) and it is ‘impossible’ to become N saturated requiring a pause on the way up. Fact. You wait 2 hours and don’t go below ~ 80′ on the second dive, and depending upon one’s health and strength you should hopefully get ~ 45 mins X 2 of ‘fun’.

    After 2 dives most will say that was great and it is time to get back and make cocktails. Anyone who does not fall under that description of ‘diving’ is likely in the 10% club and so be it.

    Discovered that maybe 2-3 dives out of 10 were worth it and memorable. And that ratio is with a little luck. Most dives (after the ‘thrills’ of the first 25) are boring and crappy. Just like skiing when it is too cold / too wet / too crowded / too boring (I’m a ski instructor as well) there are great days – and ones where all you can think about is getting the hell off the mountain.

    Spending huge loot on an exotic dive trip can deliver miraculous memories or feel like you got ripped off. Whether the Caribbean or South Pacific, storms, currents, and other uncontrollable externalities can and will deliver 15′ visibility when the day before it was 150′. May hurt your brain listening to the couple who just completed their PADI ‘open water’ in some rock pond in North Carolina, but that’s is the is.

    Those 2 out of 10′ good dives may (and will if you keep trying) present memories, unlike any other sport/activity. That’s why we do it – right?

    Gave up on wearing dry suits and the plethora of ‘advanced diving gear’ long ago as there is nothing like a shorty in warm waters. If something goes wrong, it is way better to deal with a BC / extra reg / weight belt without gloves on. Trust me.

    Diving is great – the way we treat our planet not so much. Had unbelievably beautiful dives in across the great state of Hawaii. That was then. The same places with multicolored, healthy coral and ‘thousands’ of aquatic wildlife swimming and encompassing your entirety, and what became a vision never to be forgotten, are now gray, lifeless, underwater deserts. It makes me cry. To take (insist) a ‘new diver’ join you to see what had thrilled you to nirvana and upon arrival, you can tell – even through the mask – they are thinking, ‘Huh? Where?’ He thought this was cool?

    So sad…

    Hope all get to see some great things. Per safety – not being an idiot – just keep the depths ‘normal’ (over a 100′ should be infrequent) and with 2 dives a day – you will never have to worry about ‘anything’ except your ability to get to the top on your own and without any help – as there WILL be an event that shall test that ability.

    Finding ‘wonder’ takes time and effort. It is worth it – and it can be done without all the inputs others say you need. Cheers and good luck!

    Reply